Tigecycline
نویسندگان
چکیده
منابع مشابه
Tigecycline and overall mortality.
TO THE EDITOR—Two systematic reviews and meta-analyses on the efficacy of tigecycline were performed and published in parallel [1–2]. They have reached similar conclusions, that overall mortality was increased in patients given tigecycline. This difference reached significance when all studies were included in our systematic review and meta-analysis [1]. In March 2012, Prasad et al [3] publishe...
متن کاملTigecycline pharmacokinetic/pharmacodynamic update.
This brief review summarizes recently published data on the pharmacokinetics and pharmacodynamics of tigecycline in man. Significant pharmacokinetic data are now available from the studies of infected patients, as is information on tissue distribution. Importantly, drug exposure-response relationships have been established for complicated skin and skin structure infections and intra-abdominal i...
متن کاملRe-defining tigecycline therapy.
Tigecycline, the first member of the glycylcyclines, has been approved for complicated skin and soft tissue infections (cSSTIs) and complicated intra-abdominal infections (cIAIs). It has a wide range of activity against Gram-positive and Gram-negative bacteria, including anaerobes. Since its approval, the worldwide clinical use of tigecycline has been heterogeneous, either as a monotherapy or a...
متن کاملTigecycline: an overview and update
Tigecycline is the f irst glycylcycline anti microbial to be approved in the USA and Canada. It is derived from minocycline and has sufficient novel modification to be con sidered a new class of compound [1]. The drug is active in vitro and clinically against Gram positive and negative pathogens, and atypical, anaerobic and drugresistant bacteria – includ ing multidrugresistant strains. ...
متن کاملGuideline: appropriate use of tigecycline.
INTRODUCTION Tigecycline, the first of a new class of antibiotics, the glycylcyclines, was licensed in South Africa for the parenteral treatment of adult patients with complicated intra-abdominal infections (cIAIs) and complicated skin and soft-tissue infections (cSSTIs). METHODS A multidisciplinary meeting representative of the Association of Surgeons of South Africa, the Critical Care Socie...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2005
ISSN: 1460-2091,0305-7453
DOI: 10.1093/jac/dki248